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HIVManagement.org |
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dolutegravir |
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Detailed Prescribing Information |
| Dolutegravir = Tivicay | |
| Dosing Forms | 50 mg tablets |
| Dosing | 50 mg once a day for persons who harbor HIV WITHOUT integrase strand transfer inhibitor (INSTI) mutations; 50 mg twice a day for person WITH integrase strand transfer inhibitor (INSTI) mutations |
| Hepatic insufficiency: No adjustment is necessary for mild to moderate hepatic impairment. There is no information regarding severe hepatic insufficiency. | |
| Renal insufficiency: No adjustment needed | |
| Food dependence | May be taken with or without food |
| Adverse Effects | Side effects appear to be very similar to placebo |
| Interactions |
Rifampin: adjust dose of dolutegravir to 50 mg twice a day Efavirenz: adjust dose of dolutegravir to 50 mg twice a day Ritonavir-boosted fosamprenavir: adjust dose of dolutegravir to 50 mg twice a day Ritonavir-boosted tipranavir: adjust dose of dolutegravir to 50 mg twice a day Substitutes for the drugs listed above should be used if possible. |
| Contraindications | None |
| Suggested laboratory evaluations | Based on background antiretroviral therapy |
| Warnings | None |
| Full Prescribing Information | http://www.tivicay.com |
| Links to Antiretroviral Sections |
| Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI) |
| AZT | ddI | d4T | 3TC | ABC | FTC | TDF ||| Coformulation NRTI: Combivir | Trizivir | Epzicom | Truvada |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) |
| efavirenz | nevirapine | delavirdine | etravirine | rilpivirine |
| Protease Inhibitors (PI) | Boosted Protease Inhibitors |
| saquinavir | indinavir | ritonavir | nelfinavir | lopinavir + ritonavir | atazanavir | fosamprenavir | tipranavir |
| Co-receptor Inhibitors |
| maraviroc |
| Fusion Inhibitors |
| enfuvirtide |
| Integrase Inhibitors |
| raltegravir | elvitegravir | dolutegravir |
| Antiretroviral Metabolic Inhibitors |
| cobicistat | ritonavir |
| Coformulations |
| Atripla (efavirenz/tenofovir/emtricitabine) | Complera (rilpivirine/tenofovir/emtricitabine) | Stribild (elvitegravir/cobicistat/tenofovir/emtricitabine) |
Updated 11/10/2013