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tipranavir |
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Detailed Prescribing Information |
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October 2005 |
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Tipranavir = Aptivus |
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| Dosing Forms | 250 mg gel caps |
| Dosing |
2x250 mg twice a day + 2x100 mg ritonavir
twice a day, both
with food The drug is always administered with ritonavir. |
| Hepatic impairment: Tipranavir should not be taken with moderate or severe hepatic impairment. | |
| Food dependence | Tipranavir should be taken with food. |
| Adverse Effects |
Diarrhea, nausea & vomiting,
rash (14% females, 8-10% males) Elevated liver enzymes/hepatitis Also perioral paresthesia, hepatitis, fat redistribution, hyperlipidemia, Type 2 diabetes |
| Contraindications |
Rifampin Other protease inhibitors aside from ritonavir: levels of other PIs are reduced to subtherapeutic levels |
| Interactions | When used with ethinyl estradiol - 33% chance of rash |
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statins, certain antiarrhythmics, ergot
derivatives, antihistamines, neuroleptics, sedatives - similar to other
protease inhibitors (inhibitors of CY3PA) Protease inhibitors: levels of other PIs are reduced to subtherapeutic levels NNRTIs: no dose adjustment is required for tipranavir/ritonavir when used with other NNRTIs |
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| Suggested laboratory evaluations | Liver profile and glucose monthly x 3 months, then every 3-4 months; lipid profile q3-4 months |
| Warnings | Tipranavir contains a sulfonamide component. Use cautiously in persons with sulfonamide allergy. |
| Usage Suggestions | The drug has been studied primarily as salvage therapy and appears active in the setting of multiple protease inhibitor mutations. |
| Full Prescribing Information |
http://www.aptivus.com Patient information sheet HERE. |
| Links to Antiretroviral Sections (click on anything) |
| Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI) |
| AZT | ddC | ddI | d4T | 3TC | ABC | FTC | TDF | Combivir | Trizivir | Epzicom | Truvada |
| Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI) |
| efavirenz | nevirapine | delavirdine |
| Protease Inhibitors (PI) | Boosted Protease Inhibitors |
| saquinavir | indinavir | ritonavir | nelfinavir | amprenavir | lopinavir + ritonavir | atazanavir | fosamprenavir | tipranavir |
| Fusion Inhibitors |
| enfuvirtide |
Updated 11.6.2005
