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delavirdine

Detailed Prescribing Information

October 2005

 

Delavirdine = Rescriptor
Forms Available 100 mg tabs
Dosing 4x100 mg three times a day
Contraindication Concomitant rifampin, alprazolam, midazolam, triazolam, pimozide, or ergot derivative therapy

St John's Wort is expected to decrease delavirdine levels and therefore should not be used

Simvastatin, lovastatin
Severe hypersensitivity to nevirapine

Adverse Effects

33% incidence of rash, usually mild and NONPROGRESSIVE with continued treatment

5% of persons with rash will develop, mucosal involvement, and/or

Stevens-Johnson syndrome (aka erythema multiforme major)

Hepatitis which may be severe

Interactions

Increases PI levels

Antacids and proton pump inhibitors inhibit absorption of delavirdine

Suggested lab follow-up  Liver profile at 14 days, 30 days, and monthly x 3 months, then q3months
Warning Low barrier to one-step mutation.  Use only with other potent agents.
Complete prescribing information http://www.rescriptor.com

 

 

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Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI)
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Nonnucleoside Reverse Transcriptase Inhibitors (NNRTI)
efavirenz  |  nevirapine  |  delavirdine
Protease Inhibitors (PI)  |  Boosted Protease Inhibitors
saquinavir  indinavir  |  ritonavir  |  nelfinavir  |  amprenavir  |  lopinavir + ritonavir  |  atazanavir  |  fosamprenavir  | tipranavir
Fusion Inhibitors
enfuvirtide

 

 
Quick Menu / Table of Contents
Introduction Principles Management NRTI Info NNRTI Info
PI Info Fusion Inhibitors Drug Summary Investigational Adherence
Lab Evaluation Resistance Tests PEP Antiretroviral Tables OI Prevention
Vaccinations TB Therapy Hepatitis Therapy OI Diagnosis OI Therapy
Bibliography Links Palliative Therapy

 

Updated 10.25.2005